Hi! I’m Andy.
I like to tell stories with data.
Evidence-based, reproducible narratives.
Findable, accessible, interoperable, reusable (FAIR) and robust
data.
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Technical translation
The unifying thread of my
interdisicplinary background is
analyzing data to craft stories that tell
us something about the world. Most
recently, this has been evaluating and
communicating results of three
spectacular programs at the NIH
including the Transformational
CryoEM program and the Molecular
Transducers of Physical Activity
Consortium (MoTrPAC).
Here are some of my public work products:
Biophysics and
Bioinformatics
During my PhD, I studied how a group of enzymes required for life respond to molecular signals. With techniques like small-angle X-ray scattering and evolutionary analysis, we uncovered informaiton about how and why these proteins evolved the way they did. In my postdoc, I used bioinformatics to analyze large datasets of enzymes that bind carbohydrates, creating rules that help predict which proteins will bind these very important molecules.
Science
Communication
Throughout my technical training, I have always loved using science to communicate with others. I have written for the science blog MicroBites and participated as a member of the Science Policy Discussion Group at the NIH. I have also taken a variety of communications training including media relations, communicating to diverse audiences, and communicating program evaluation results to name a few.
Here are some of my public work products:
What’s my whole deal?
Jul 2017
-
May 2023
Bachelors in Chemistry
from Bryn Mawr College
Aug 2013
-
May 2017
May 2023
-
Apr 2024
Postdoc at the National
Center for Biotechnology
Information
Communications and
Evaluations at the NIH
Common Fund
Apr 2024
-
Feb 2025
PhD in Chemistry and
Chemical Biology from
Cornell with Prof.
Nozomi Ando
Andy Burnim, PhD: where’s he been?
Publications
Diribonuclease activity eliminates toxic diribonucleotide accumulation. Cell Rep 43, 114759 (2024).
doi:10.1016/j.celrep.2024.114759
Conformational landscapes of a Class I ribonucleotide reductase complex during turnover reveal intrinsic dynamics and
asymmetry. bioRxiv (2024). doi:10.1101/2024.06.16.599213
The three-sided right-handed β-helix is a versatile fold for glycan interactions. Glycobiology 34 (2024).
doi:10.1093/glycob/cwae037
Conformational switching and flexibility in cobalamin-dependent methionine synthase studied by small-angle X-ray
scattering and cryo-electron microscopy. Proc. Natl. Acad. Sci. USA 120, 2302531120 (2023).
doi:10.1073/pnas.2302531120
Analysis of insertions and extensions in the functional evolution of the ribonucleotide reductase family. Protein Sci. 31
(2022). doi:10.1002/pro.4483
Comprehensive phylogenetic analysis of the ribonucleotide reductase family reveals an ancestral clade and the role of
insertions and extensions in diversification. eLife (2022). doi:10.7554/eLife.79790
Communications I’ve Authored for a Public Audience
Some Projects Worth a Mention
So What?: Skills and Competencies
Protein purificiation, ligand binding analysis
Molecular dynamics, phylogenetic inference
Generating and maintaining SOPs
Techincal and non-technical communication
Social media
Data visualization
Data for decision making
Impact analysis
Data informed stategy
Project management
Strategic planning
Coordination
R, Python, Matlab, Jupyter, git/GitHub
Microsoft suite, Adobe suite, Canva
HPC Linux environments, Globus